Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives
نویسندگان
چکیده
منابع مشابه
Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.
BACKGROUND The relationship between neuropathological lesions and mild, "preclinical," cognitive impairments of Alzheimer disease is poorly understood. Identification of the lesions that are most closely associated with the earliest symptoms of Alzheimer disease is crucial to the understanding of the disease process and the development of treatment strategies to affect its progression. DESIGN...
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Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer's disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might b...
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INTRODUCTION Neurodegenerative diseases are a major cause of cognitive impairment and can ultimately lead to dementia. Genome-wide association studies have uncovered many genetic variants conferring risk of neurodegenerative diseases, but their role in cognitive impairment remains unexplored. METHODS In the prospective, population-based Rotterdam Study, 3605 nondemented persons aged ≥55 years...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2019
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-190011